![]() ![]() ![]() Researchers typically encode genes to be expressed on circular pieces of DNA called plasmids. Those rooms might be too hot, so a solution would be to have thermostats on each heater to downregulate the heat when a room becomes too hot. To ensure each room gets a heater you would purchase some extra ones, but that would mean some rooms might have extra heaters. ![]() Imagine using randomly placed space heaters to heat your home. The researchers use an analogy of heating a house to help explain how Equalizers work. This property is called "gene dosage compensation." The findings, in the current edition of Nature Communications, show how researchers engineered these genetic circuits to buffer protein output from variations in the number of copies of the gene inside the cell, thereby helping to create consistent protein expression.
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